Human-Antigen R (HuR) Expression in Hypertension

Human-antigen R (HuR) expression in hypertension: downregulation of the mRNA stabilizing protein HuR in genetic hypertension.

In aged spontaneously hypertensive rats (SHR), vasorelaxant responses to NO are attenuated compared with normotensive control rats (Wistar-Kyoto [WKY]) because of a decreased expression of the important NO receptor soluble guanylyl cyclase (sGC). Because the expression of sGC subunits alpha1 and beta1 is controlled at the post-transcriptional level by the mRNA-binding protein human-antigen R (H...

Transcriptional Control of Human Antigen R (hur) by Bone Morphogenetic Protein (bmp) *

MORPHOGENETIC PROTEIN (BMP) * Selvi C. Jeyaraj, Mamata Singh, Dina A. Ayupova, Suman Govindaraju, and Beth S. Lee From the Department of Physiology and Cell Biology, The Ohio State University College of Medicine, Columbus, OH 43210 Running title: Transcription of HuR by BMP Address correspondence to: Beth S. Lee, Department of Physiology and Cell Biology, The Ohio State University, 304 Hamilton...

Human platelet antigen polymorphism in bronchial asthma

Background: Asthma is recognized as a common cause of disability, of great economic cost, and of preventable deaths. In this study we aimed to test our hypothesis to evaluate the relationship between the Human Platelet Antigen-1(HPA-1) polymorphism and bronchial asthma and its severity, which would suggest genetic variances that may be responsible for expression or activation of these receptors...

Regulated Expression of Fc R in Human Dendritic Cells Controls Cross-Presentation of Antigen-Antibody Complexes

Downregulation of the mRNA Stabilizing Protein HuR in Genetic Hypertension

In aged spontaneously hypertensive rats (SHR), vasorelaxant responses to NO are attenuated compared with normotensive control rats (Wistar-Kyoto [WKY]) because of a decreased expression of the important NO receptor soluble guanylyl cyclase (sGC). Because the expression of sGC subunits 1 and 1 is controlled at the posttranscriptional level by the mRNA-binding protein human-antigen R (HuR), we no...